Selected Publications with Signalling Factory Contribution

Signalling Factory

2021

Designed membrane protein heterodimers and control of their affinity by binding domain and membrane linker properties.
Lan C, Stulz A, Barthes NPF, Lauw S, Salavei P, Jung M, Heerklotz H, Ulbrich MH.
Nanoscale. 2021 Dec 16;13(48):20692-20702. doi: 10.1039/d1nr06574b. PMID: 34878479

Bacterial lectin BambL acts as a B cell superantigen.
Frensch M, Jäger C, Müller PF, Tadi? A, Wilhelm I, Wehrum S, Diedrich B, Fischer B, Meléndez AV, Dengjel J, Eibel H, Römer W.
Cell Mol Life Sci. 2021 Dec;78(24):8165-8186. doi: 10.1007/s00018-021-04009-z.

Cardiomyocyte-specific miR-100 overexpression preserves heart function under pressure overload in mice and diminishes fatty acid uptake as well as ROS production by direct suppression of Nox4 and CD36
Smolka C, Schlösser D, Koentges C, Tarkhnishvili A, Gorka O, Pfeifer D, Bemtgen X, Asmussen A, Groß O, Diehl P, Moser M, Bode C, Bugger H, Grundmann S, Pankratz F.
FASEB J. 2021 Nov;35(11):e21956. doi: 10.1096/fj.202100829RR.

finDr: A web server for in silico D-peptide ligand identification.
Engel H, Guischard F, Krause F, Nandy J, Kaas P, Höfflin N, Köhn M, Kilb N, Voigt K, Wolf S, Aslan T, Baezner F, Hahne S, Ruckes C, Weygant J, Zinina A, Akmeriç EB, Antwi EB, Dombrovskij D, Franke P, Lesch KL, Vesper N, Weis D, Gensch N, Di Ventura B, Öztürk MA.
Synth Syst Biotechnol. 2021 Nov 23;6(4):402-413. doi: 10.1016/j.synbio.2021.11.004.

MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice.
Smolka C, Schlösser D, Hohnloser C, Bemtgen X, Jänich C, Schneider L, Martin J, Pfeifer D, Moser M, Hasselblatt P, Bode C, Grundmann S, Pankratz F.
Mol Med. 2021 Sep 6;27(1):101. doi: 10.1186/s10020-021-00364-6.

Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells
Kern U, Fröhlich K, Bedacht J, Schmidt N, Biniossek ML, Gensch N, Baerenfaller K, Schilling O.
Cells. 2021 Feb 16;10(2):404. doi: 10.3390/cells10020404.

 

2020

Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytes.
Jumaa H, Caganova M, McAllister EJ, Hoenig L, He X, Saltukoglu D, Brenker K, Köhler M, Leben R, Hauser AE, Niesner R, Rajewsky K, Reth M, Jellusova J.
Life Sci Alliance. 2020 Apr 27;3(6):e202000700. doi: 10.26508/lsa.202000700.

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A
Hoermann B, Kokot T, Helm D, Heinzlmeir S, Chojnacki JE, Schubert T, Ludwig C, Berteotti A, Kurzawa N, Kuster B, Savitski MM, Köhn M.
Nat Commun. 2020 Jul 17;11(1):3583.doi: 10.1038/s41467-020-17334-x.

 

2019

Comparison of different label-free imaging high-throughput biosensing systems for aptamer binding measurements using thrombin aptamers
Rath C, Burger J, Norval L, Kraemer SD, Gensch N, van der Kooi A, Reinemann C, O'Sullivan C, Svobodova M, Roth G.
Anal Biochem. 2019 Oct 15;583:113323. doi: 10.1016/j.ab.2019.05.012. .

A Monoallelic Two-Hit Mechanism in PLCD1 Explains the Genetic Pathogenesis of Hereditary Trichilemmal Cyst Formation
Hörer S, Marrakchi S, Radner FPW, Zolles G, Heinz L, Eichmann TO, Has C, Salavei P, Mahfoudh N, Turki H, Zimmer AD, Fischer J.
J Invest Dermatol. 2019 Oct;139(10):2154-2163.e5. doi: 10.1016/j.jid.2019.04.015.

Production of Phytochromes by High-Cell-Density E. coli Fermentation
Hörner M, Gerhardt K, Salavei P, Hoess P, Härrer D, Kaiser J, Tabor JJ, Weber W.
ACS Synth Biol. 2019 Oct 18;8(10):2442-2450.doi: 10.1021/acssynbio.9b00267.

 

2018

Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells.
Baaske J, Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA, Minguet S, Davies JA, Timmer J, Weber W, Zurbriggen MD.
Sci Rep. 2018 Oct 9;8(1):15024.

Multiplexed antibody detection from blood sera by immobilization of in vitro expressed antigens and label-free readout via imaging reflectometric interferometry (iRIf).
Bender J, Bognar S, Camagna M, Donauer JAM, Eble JW, Emig R, Fischer S, Jesser R, Keilholz L, Kokotek DMU, Neumann J, Nicklaus S, Oude Weernink RRQPT, Stühn LG, Wössner N, Krämer SD, Schwenk P, Gensch N, Roth G, Ulbrich MH.
Biosens Bioelectron. 2018 Sep 15;115:97-103.

Anti-CD3 Fab Fragments Enhance Tumor Killing by Human gamma delta T Cells Independent of Nck Recruitment to the gamma delta T Cell Antigen Receptor.
Juraske C, Wipa P, Morath A, Hidalgo JV, Hartl FA, Raute K, Oberg HH, Wesch D, Fisch P, Minguet S, Pongcharoen S, Schamel WW.
Front Immunol. 2018 Jul 9;9:1579.

Miniature scanning light-sheet illumination implemented in a conventional microscope
Bhat Kashekodi A, Meinert T, Michiels R, Rohrbach A
Biomed Opt Express, 2018 Sep 1 Vol. 9, No. 9; 4263 - 4274

OptoBase: A web platform for molecular optogenetics.
Kolar K, Knobloch C, Stork H, Žnidaric M, Weber W.
ACS Synth Biol. 2018 Jul 20;7(7):1825-1828.

Synthetic Biology Makes Polymer Materials Count.
Beyer HM, Engesser R, Hörner M, Koschmieder J, Beyer P, Timmer J, Zurbriggen MD, Weber W.
Adv Mater. 2018 May;30(21):e1800472.

Lectin-mediated protocell crosslinking to mimic cell-cell junctions and adhesion.
Villringer S, Madl J, Sych T, Manner C, Imberty A, Römer W.
Sci Rep. 2018 Jan 31;8(1):1932.

 

2017

PCH1 and PCHL promote photomorphogenesis in plants by controlling phytochrome B dark reversion.
Enderle B, Sheerin DJ, Paik I, Kathare PK, Schwenk P, Klose C, Ulbrich MH, Huq E, Hiltbrunner A.
Nat Commun. 2017 Dec 20;8(1):2221.

Disordered Conformation with Low Pii Helix in Phosphoproteins Orchestrates Biomimetic Apatite Formation.
Sarem M, Ludeke S, Thomann R, Salavei P, Zou Z, Habraken W, Masic A, and Shastri VP
Adv Mater. 2017 Sep;29(35).

Gene regulation during Drosophila eggshell patterning
George Pyrowolakis, Ville Veikkolainen, Nir Yakoby, and Stanislav Y. Shvartsman
PNAS June 6, 2017 114 (23) 5808-5813

Mutations in SULT2B1 Cause Autosomal-Recessive Congenital Ichthyosis in Humans
Lisa Heinz, Gwang-Jin Kim, Slaheddine Marrakchi, Julie Christiansen, Hamida Turki, Marc-Alexander Rauschendorf, Mark Lathrop, Ingrid Hausser, Andreas D. Zimmer, and Judith Fischer
Am J Hum Genet. 2017 Jun 1;100(6):926-939.

Sex-Specific Transcript Diversity in the Fly Head Is Established during Pupal Stages and Adulthood and Is Largely Independent of the Mating Process and the Germline.
Mohr C, Kleiner S, Blanchette M, Pyrowolakis G, Hartmann B.
Sex Dev. 2017;11(2):94-108.

Diedrich B, Rigbolt KT, Röring M, Herr R, Kaeser-Pebernard S, Gretzmeier C, Murphy RF, Brummer T, Dengjel J.
Discrete cytosolic macromolecular BRAF complexes exhibit distinct activities and composition.
EMBO J. 2017 Mar 1;36(5):646-663.

Gb3-binding lectins as potential carriers for transcellular drug delivery.
Müller SK, Wilhelm I, Schubert T, Zittlau K, Imberty A, Madl J, Eierhoff T, Thuenauer R, Römer W.
Expert Opin Drug Deliv. 2017 Feb;14(2):141-153.

Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells.
Zahaf NI, Lang AE, Kaiser L, Fichter CD, Lassmann S, McCluskey A, Augspach A, Aktories K, Schmidt G.
Sci Rep. 2017 Jan 27;7:41252.

 

2016

Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.
Keller B, Zaidman I, Yousefi OS, Hershkovitz D, Stein J, Unger S, Schachtrup K, Sigvardsson M, Kuperman AA, Shaag A, Schamel WW, Elpeleg O, Warnatz K, Stepensky P.
J Exp Med. 2016 Jun 27;213(7):1185-99.

Pentagone internalises glypicans to fine-tune multiple signalling pathways.
Norman M, Vuilleumier R, Springhorn A, Gawlik J, Pyrowolakis G.
Elife. 2016 Jun 8;5. pii: e13301.

Nck Binds to the T Cell Antigen Receptor Using Its SH3.1 and SH2 Domains in a Cooperative Manner, Promoting TCR Functioning.
Paensuwan P, Hartl FA, Yousefi OS, Ngoenkam J, Wipa P, Beck-Garcia E, Dopfer EP, Khamsri B, Sanguansermsri D, Minguet S, Schamel WW, Pongcharoen S.
J Immunol. 2016 Jan 1;196(1):448-58.

Signalling to the nucleus under the control of light and small molecules.
Juillot S, Beyer HM, Madl J, Weber W, Zurbriggen MD, Römer W.
Mol Biosyst. 2016 Feb;12(2):345-9.

 

2015

Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW.
J Exp Med. 2015 Sep 21;212(10):1693-708.

Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish.
Beyer HM, Juillot S, Herbst K, Samodelov SL, Müller K, Schamel WW, Römer W, Schäfer E, Nagy F, Strähle U, Weber W, Zurbriggen MD.
ACS Synth Biol. 2015 Sep 18;4(9):951-8.

AQUA Cloning: A Versatile and Simple Enzyme-Free Cloning Approach.
Beyer HM, Gonschorek P, Samodelov SL, Meier M, Weber W, Zurbriggen MD.
PLoS One. 2015 Sep 11;10(9):e0137652.

 

2014

B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.
Kläsener K, Maity PC, Hobeika E, Yang J, Reth M.
Elife. 2014 Jun 24;3:e02069.

The CD3 conformational change in the gamma delta T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.
Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillán B, Sandstrom A, Alarcón B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WWA.
Cell Rep. 2014 Jun 12;7(5):1704-1715.

Enzymatic Fuel Cells Solely Supplied with Unpurified Cellobiose Dehydrogenase and Laccase in Microorganism’s Culture Supernatants.
Sané S, Heilemann C, Salavei P, Rubenwolf S, Jolivalt C, Madzak C, Zengerle R, Nielsen PJ and Kerzenmacher S
ChemElectroChem. 2014;1(11):1886-1894